The Alpine Space economy is largely based on manufacturing SMEs and clusters are a powerful tool to enhance competitiveness. The establishment of transnational clusters networks is a step forward to favour cross-border cooperation although poor awareness of the potentialities from the addressees and the lack of self-sustainability in the medium and long term are still real barriers. AlpClusters2020 aims to contribute to the design of an integrated policy approach for the support of transnational clusters networks at ALPINE space level, in order to: -facilitate the emergence of new industries, enhancing the resilience of Alpine industrial ecosystem -track and valorise the achievements of the previous supported initiatives, assessing their impact -animate a deep and intense participatory process through which private and public relevant actors can take part in the design of future actions -support policy development process, exploring the synergies and suggesting joint actions toward 2020.