The aim of the project is to reduce administrative burden for entrepreneurs in Latvia-Lithuania cross-border regions by improving business environment and making region better for the businesses. The first phase of the project analysed the administrative burden in Jelgava and Siauliai cities and estimated that directly or indirectly business-related administrative burden in Jelgava and Siauliai amounted to EUR 3.2 million per year. The indicative extrapolations made by Lithuanian and Latvian researchers show that the administrative burden in Latvia – Lithuania cross-border regions in total amounts to EUR 36 million per year. According to researchers’ of the Latvian University of Agriculture administrative burden will double every year for the next 5-7 years. Although Jelgava and Siauliai, in general, are considered business-friendly cities, researchers together with municipal specialists have found out a range of possible administrative burden reduction measures. The research made for Jelgava indicates more than 80 proposals on changes to be made at municipal and national level. For entrepreneurs and citizens of Jelgava it would mean reduction of annual administrative burden by 42%. The research made for Siauliai indicates 21 proposals on changes to be made at municipal and national level. The implementation of such would reduce administrative burden by 40%. The next phase of the project includes implementation of proposals by making changes in municipal binding regulations, as well as initiating changes in legislation at national level.