The cultural and creative (CC) sectors are some of Europe’s most dynamic sectors, with a 4.2% of total EU GDP generated. These sectors, often clusters suffer the lack of conjunctions between their CC components, making the cultural core still unable to fully express its potential in terms of fertilization of creative industries. In this conditions these sectors remain undervalued and unrecognised, especially in terms of their ability to access start-up capital and financing. One of the main challenges in these clusters is improving the connections between the cultural core engines and creativity in order to make the best of the synergies between the wealth of heritage traditions, values and symbols and the business environment that can add to them economic value and fully exploit their economic potential. SMATH’s main goal is to improve the quality and quantity of connections between the publicly oriented domain of culture and the business oriented domain of creativity via innovative forms of clustering “Smart Atmospheres”. SMATH intends to generate and strengthen “Smart Atmospheres” able to support the start-up and the development of SMEs in the CC sector facilitating the access to “culture factories” and value enhancing services (private and public finance) and the development of innovative clustering on CCIs level and the setting-up of joint cooperation at PPPs among investors and public actors able to exploit their potential to support the growth in the MED Area.