The main functions of excellence are performed by the historical centres and their heritage, where the Euro-Mediterranean culture and knowledge are concentrated. An innovating, dynamic approach is adopted to increase the cities’ attractiveness, so as to enhance competences and favour the inclusion of different social groups. The cultural heritage of the Mediterranean territories, their traditions, history and culture, are very important factors leading to a major economic development process. This heritage is often neglected or is not sufficiently protected against the elements leading to its degradation and ruin. In this context, the UNESCO Cities enable an interdisciplinary approach based on an integrated management and on recognising the added value of pursuing the goal of revitalising the urban texture of historical centres by means of innovating actions aimed at enhancing the cultural heritage in a diversified environment with a few common challenges. The project (CULTURE Cités Unesco Laboratoires de Territoires URbains) thus aims at identifying and sharing transnational governance methods by developing a common strategy for an integrated local development aimed at managing historical city centres by valorization of cultural heritage through the sharing and implementing a transnational action plan, innovating cultural activities and services to increase the economic attractiveness of the historical city centres involved.