The natural and cultural heritage of the Italy-France Maritime Cooperation Programme represents a significant development opportunity made vulnerable by natural and humanmade risks, the widening inequalities between coast and inland and the effects of the economic crisis. The natural and cultural heritage is poorly used and difficult to manage; there is little coordination between institutions, not enough infrastructure and innovative technologies, loss of biodiversity and aesthetic degradation of the landscape. CAMBIO VIA aims to improve the effectiveness of public actions in protecting, promoting and developing the natural and cultural heritage represented by protected areas, parks and historic sites along the transhumance route. The physical and intellectual enjoyment of the rich cross-border and island heritage will be enhanced to test a new network model recognising the economic, historical, cultural, tourism and environmental value of the traditional products, biodiversity and rural paths of Tuscany, Liguria, Sardinia, Southern Region and Corsica. The cooperation value lies in the creation of an integrated and multidisciplinary natural and cultural offer improving the attractiveness and competitiveness of the area and islands. The outcomes will be a strategic action plan, charter of guardian communities, methodology defining high environmental quality products, transhumance label, collection of good practices and tutorials on agricultural entrepreneurship, georeferenced transboundary itinerary and actions to improve physical and intellectual heritage accessibility. The beneficiaries will be local communities, public institutions, parks, protected areas and tourists. The innovation lies in the substantial interaction between geo-environmental and cultural specificities leading to greater areal continuity and the enhancement of common values through multimedia techniques.