The University Innovation Center of Andalusia, Alentejo and Algarve (CIU3A), is a joint innovation center of the universities of Seville, Évora and Algarve specialized in Industry 4.0, Logistics, Materials and Sustainability. It comprises a set of facilities and equipment and R + D + i activities. The cross-border nature makes it possible to take advantage of collaboration and complementarity between universities, economies of scale and the possibility of forming a logistic axis.