CITYREGIO addresses the problems arising from different paces and accents of economic development between centres and their surrounding areas and the problems of their impact on spatial development. The project analyses the mutual interdependence of centres and their surroundings. It approaches cities and the surrounding districts as a unity as far as regional economic development is concerned. From this perspective traditional administrative areas become obstacles. Issues of economic development, spatial planning, location management, and development of human resources and capacities cannot be adequately addressed by local and regional authorities without close co-operation. CITYREGIO addresses this problem in transnational cooperation with the regions of Linz (Austria), Plzen (Czech Republic) and Leipzig (Germany), which are characterised by a number of similar development issues and by geographical proximity in the central CADSES area.