While Franco-Belgian cross-border cooperation in the field of health has made significant progress within the EU framework as regards access to quality local care, some areas remain unexplored. The COPROSEPAT project focuses on prevention and therapeutic patient education (TPE) while supporting a dynamic of health cooperation. It also aims to provide answers to the development of chronic diseases and, therefore, to deploy prevention and TPE actions with regard to cardiovascular diseases, diabetes, etc., based on cross-border health cooperation. On the basis of this intervention logic, the project partnership proposes to carry out a shared health diagnosis of the border territory; harmonise TPE practices in cooperation with health professionals; set up TPE actions to strengthen the power the chronically ill patient has over his or her health; strengthen access to care and TPE for the most vulnerable people; deepen the complementarity between the two sides of the border in terms of health and medico-social issues to integrate this new field of action.