Alpine SMEs are rather small and with low attitude to innovation processes according to the social and technological changes, at the present required by the new users’ needs, the business model approached characterized by the mountain areas and the need to enter into foreign markets with new strategies and effectiveness. The change required by the enterprises is to be intended not only as investments for new technologies, but even the need to give new “meaning” to the traditional products and services and more attitude to meet users’ needs and expectations. These contributes can be found from one side with an effective collaboration of SMEs with Cultural and Creative Industries (CCIs) (digital, multimedia, graphic, creative practitioners and professionals, etc.) and from the other with the valorization of cultural (museum, theater, musical and cultural exhibition, cultural heritage, traditional events, etc.) and natural assets (Dolomite, natural parks, rivers, etc) that are the “proprium” of the are where SMEs are located and produce. CROSSINNO aims at strengthening the quality of the services offered to SMEs to increase the quantity and quality of innovation processes: setting-up a virtuous chain with traditional SMEs from agro-food, tourism, wood-chain, Cultural and Creative Industries and cultural/natural assets that can become “engines” for SMEs’ growth. CROSSINNO aims at elaborating a collaboration model to strengthen the relationship above described.