Mechanics, building and furniture are traditional MED sectors with a great impact in terms of GDP and employability.These sectors,often clusters,are suffering a lack of innovation able to strengthen their competitiveness in domestic and international markets. The competition from others countries is strong and social trends required new solution: innovation is necessary to win competitors. Actually, the generation of ideas for new products and services according to social and technological trends is one of the main challenge for these clusters. Co-Create objective is to support cross-fertilization processes between creative industries and traditional clusters contributing to test co-design and creative methods applied to entrepreneurs and clusters managers with the support of IPR instruments for their management. The project will promote the cooperation with new methodologies and tools addressed to clusters managers, SMEs and policy makers. Main outputs will be a cross-fertilization toolkit as instrument to favour innovation of Clusters and SMEs, 380 SMEs supported on innovative projects, the setting up of a transnational innovation network between traditional and creative industries and a Manifesto, to promote cross fertilization and to enlarge the network. Co-Create will also contribute to the development at MED level of more competitive clusters through the elaboration of a cross fertilization methodology and toolkit to support and manage cross-clusters initiatives