The fruit and vegetable sector is one of the largest consumers of plant protection products. The development of organic farming and the application of “zero phyto” methods in our regions is an economic, human health and environmental protection challenge. To meet these challenges and consumer concerns, it is necessary to design new production systems, which is what the project aims to do by combining complementary skills within the cross-border basin. The objective of this project is to identify, validate and transmit practical keys to be able to produce fruit and vegetables without any spraying of plant protection products. Different solutions exist but there is still a lack of real understanding of the agronomic aspects, crop diversification, physical control, knowledge of key diseases and pests, alternative methods of protection without inputs, etc. Proven methods are disseminated to all stakeholders in the sector, from producers to consumers.