APICE proposes a decision-making approach & related set of mitigation measures that assume the impact of air pollution sources as driver for the coast management in port-cities. This model is based on a stronger coordination of environmental and spatial planning policies, leading to curb emissions and preserving economic potentialities of port-cities. Results will be owned by some of the main MED port-cities to move towards the attainments of the key objectives of EU Integrated Maritime Policy