Due to its very high rate of urbanisation, 93% of the France-Wallonia-Flanders cross-border region is subject to massive daily flows of agricultural products, water and energy from conventional agricultural production systems (42% to 67% of the territory). These systems generate large quantities of CO2, wastewater and other waste. To increase the transfer and dissemination of good practices in the green sector in general and specifically in the agricultural sector, it is necessary to structure cross-border Research & Innovation networks, thus improving food security, providing environmental, economic and social benefits while encouraging the development of innovative solutions. Aquaponics is a relevant solution to address the problems of the France-Wallonia-Flanders cross-border region in terms of water management and food security. It is a rural and urban agricultural technique that combines plant and fish farming in a single integrated system for the sustainable, fresh and healthy production of fish and vegetables. The SMART AQUAPONICS project sets out to promote the transfer and adoption of this agricultural technique in the cross-border economic fabric. The project aims to encourage the development and demonstration of an intelligent management system for aquaponic systems, the creation of new products to be marketed to support its deployment in the cross-border region (management software, serious game) while supporting organisational and social innovation (new business models, new uses) and the dissemination of good practices (training programme). Intersectoral collaboration within the project stimulates innovation and competitiveness of cross-border companies that are partner operators in the project, and more generally stakeholders in the field of professional and urban agriculture.