An effective territorial governance can positively address an inclusive growth under different dimensions. Those targeted by the SPHERA cluster project are health and spatial planning as areas where interventions such as accessibility to services of general interest, demographic change, social cohesion and quality of life are driver towards the progress of an inclusive growth. The current Alpine Space programming period offers samples of implemented projects which can provide achievements of valuable interest in this thematic field. Learning by those results, in terms of capitalisation, the opportunity is to identify the transnational needs and the appropriate institutional framework where new synergies can be developed in view of the next generation of projects under the Alpine Space Programme 2014 +.The SPHERA project is aimed at exploring and analysing this landscape contributing to orient and influence the future of the Cohesion Policy from its specific domains perspective.