The SYSIASS project focuses on technological advancement in order to enable healthcare professionals in the 2 Seas area to take up new technology to assist with their healthcare provision. This project aims at developing an intelligent wheelchair prototype with a novel human-machine interface. This wheelchair is either controlled by the patient or autonomously and additionally provides secure communication of healthcare related data. Some algorithms developed in ACOS (a former Interreg IIIA project) can be re-used for specific aspects of the wheelchair navigation, however, it is necessary to develop new algorithms as the environment in which the chair operates is more complex and a higher level of security is required. Additional partner organisations have been included to address the significant technical challenge and specific healthcare organisations are involved to give a highly practical perspective to the project.