Ports in the Southern Mediterranean area play a key role in freight transportation, acting as the main gateways to the mainland. Their significant placement in the freight supply chain triggered the idea for an integrated management of the ports’ freight operations along with the provision and support of intermodal and multimodal services to transport operators (sea, road and rail).The main objective of the project is to promote intermodality and interregional cooperation in the 6 participant sites through the development and testing of an innovative e-platform that will provide all necessary information (departures/arrivals, capacities, transit availability etc.) to all interested parties (cargo shipping companies, road and rail cargo operators etc).Information provided will promote the use of intermodal or multimodal services in order to expand productivity, efficiency and transit capacity usage. The proposed platform will be based on state-of-the-art ICT and telematics cargo services and will be integrated to all the participant sites in order to provide intercommunication and all the necessary interfaces to the transport logistics operators. Such an approach will promote regional development, as well as robust interregional, cross-border and transnational cooperation. Furthermore, it will raise the need of such an approach on freight transport, promoting the e-Freight concept, in association with low environmental impact, while disseminating its results to public policy level.