More than 4.5 million young people (aged 15-24 years) are unemployed today in the EU. Younger generations have been hardest hit by the fallout from the global financial crisis than most other groups. Today’s situation reflects a serious and structural problem. The EU has established the Youth Guarantee to ensure that all EU Member States make a good-quality offer to all young people up to age 25 of a job, continued education, an apprenticeship or a traineeship within four months of leaving formal education or becoming unemployed. Delivering a Youth Guarantee provides the basis for major structural reform measures in the mid- and longer term. The main objective of the research is to provide territorial evidence on youth unemployment trend and to propose recommendations for how territorial cohesion policy can contribute to strengthening the resilience in European regions against youth unemployment and enhancing the implementation of the Youth Guarantee, Youth Employment and the EURES Initiatives.